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Nuclear dna topoisomerase i (top1) is an essential human enzyme, and is the only known target of the camptothecin and its derivatives This enzyme represents a novel and distinct molecule target for cancer therapy by antitopoisomerase. The mechanisms and molecular determinants of the tumour.
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In the present review, various types of topoisomerase inhibitors and their mechanisms of action have been discussed. In this article, we discuss the characteristics of topoisomerase (dna) i (top1) and its inhibitors, as well as the underlying dna repair pathways and the use of top1 inhibitors in cancer therapy. Introduction to topoisomerase inhibitors in neuro science dna topoisomerases are enzymes that regulate the topology of dna by facilitating local winding and unwinding, which is essential for relaxing torsional stress during nucleosome repositioning, transcription, and dna replication in neural cells
Dna topoisomerases i and ii (top1 and top2) are vital for gene expression, as they resolve.
Topoisomerase inhibitors in current use in the united states include irinotecan and topotecan, inhibitors of topoisomerase i, and etoposide and teniposide, inhibitors of topoisomerase ii All four agents are semisynthetic analogues of natural toxins that were initially identified in plants. Topoisomerase i inhibitors are a new class of anticancer agents with a mechanism of action aimed at interrupting dna replication in cancer cells, Introduction the dna topoisomerase enzymes are pivotal for cell function and are found ubiquitously in all domains of life [1, 2, 3, 4].
Topoisomerase ib (top1), a subcategory of dna topoisomerase enzymes is expressed much higher in several tumor cells Therefore, modulating the activity of top1 in tumor cells to prevent dna replication and subsequent cell division made it an important drug target for anticancer therapy
