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Innovations in linker design are focused on multiple issues ranging from serum stability to mechanism of release to drug to antibody ratio (dar) An ideal linker should be stable in the circulatory system and release the cytotoxic payload specifically in the tumor As linkers become increasingly sophisticated, more emphasis is being placed on the methods of bioconjugation between linker and antibody, with the goal of producing homogeneous adc populations.
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Target, antibody, linker, payload, and conjugation method. In particular, linker design plays a critical role in modulating adc stability in the systemic circulation and payload release. Linker tethering payload to antibody is vital for adc
