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Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant Trough levels are most reproducible. Transfer separated serum or plasma to a plastic transport tube
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Draw trough levels immediately prior to next dose. For storage beyond three days, specimen should be refrigerated or frozen Measurement of carbamazepine levels in serum or plasma to facilitate therapeutic or toxicity monitoring
Carbamazepine blood levels should be reviewed within the context of clinical findings, such as a change in seizure frequency.
Immunoassay (ia) turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider In some cases, additional time should be allowed for additional confirmatory or additional reflex tests Dosage adjustments are usually guided by monitoring blood levels Most patients respond well when the serum concentration is in the range of 4.0 to 12.0 mcg/ml.
Due to variability of absorption, the trough level may not represent the lowest drug level during the dosing interval, so multiple determinations may be necessary in some patients. Normal range/expected value (s) for a specific disease state May also include abnormal ranges May include disease information, patient result explanation, recommendations, or details of testing
As with the serum levels of other anticonvulsant drugs, total and free carbamazepine levels should be correlated with the patient's clinical condition
They are best used as a guide in dose adjustment. Submit serum or plasma in a plastic transport tube
